PIWI-interacting RNAs: who, what, when, where, why, and how
2024年9月26日 · Argonaute proteins and their small guide RNAs play crucial roles in genome defense and gene silencing across all branches of life. In animals, three classes of small RNAs—small interfering RNAs (siRNAs), microRNAs (miRNAs), and piRNAs—can be distinguished by their specific RNA precursors and associated Argonaute proteins (Onishi et al, 2021; Ozata et al, 2019). piRNAs are bound to members ...
Art and science: Intersections of art and science ... - EMBO reports
2018年12月27日 · Art and science have coexisted, often indistinguishable from each other, across time and space. A wealth of early documented examples comes from the Islamic culture, where art and science joined in intricate star‐shaped architectural geometries, and the use of “Nur” (light) and material science to design utensils and lettering in manuscripts 2.
MolPhase, an advanced prediction algorithm for ... - The EMBO …
2024年4月2日 · The efficiency of functional protein phase-separation relies heavily on intrinsic and environmental physical-chemical attributes. MolPhase, a machine-learning engine trained on 606 experimentally derived sequences and employing 39 physical features, effectively predicts and analyzes biophysical features associated with phase separation.
Deciphering the molecular logic of WOX5 function in the root …
2024年11月18日 · The stem cells that give rise to the different files of cell types in the root are localized around the QC cells (Dolan et al, 1993; Pardal and Heidstra, 2021; Rahni and Birnbaum, 2019): The proximal stem cells give rise to the stele, endodermis, and cortex, the lateral ones to the epidermis and the lateral root cap, and the distal stem cells to the gravity-sensing columella (Dolan et al, 1993).
Structural insights into human zinc transporter ZnT1 mediated Zn2 ...
2024年10月10日 · The ubiquitously distributed zinc ions (Zn 2+) play fundamental roles in many physiological functions (Fukada et al, 2011).Binding to ~10% proteins encoded by the human genome, Zn 2+ can act as a structural, catalytic and/or regulatory cofactor, as well as a signaling messenger (Yamasaki et al, 2007;).Nutritional zinc is critical for normal growth and development, nerve function, immune ...
The EMBO Journal
2025年1月16日 · This cover highlights the article Kinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex by Sharmin Naher, Takako Kikkawa, Noriko Osumi and colleagues. The image shows that GFP + Kif23 knockdown cells (green) precociously differentiate into neurons and migrate to the upper area in the embryonic cortex, suggesting a function of KIF23 in the ...
Scientific truth: an endangered species | EMBO reports
2024年10月24日 · The cliché about some bad apples in a barrel applies to the research community as it does to all groups and professions. There are cheats who falsify data to get a tidy result, those who copy without giving credit, those who fill in blanks in experiments because they “know” what the result would be if correctly performed.
Molecular condensation of the CO/NF-YB/NF-YC/
2024年11月20日 · Our study reveals that a multicomponent assembly consisting of CO, NF-YB, NF-YC, and FT can form functional CO assemblies that undergo molecular condensation, enabling the regulation of FT transcriptional activation. Through this process, CO proteins transition from an inactive, diffuse state, to active, nano-meter scale liquid functional condensates, facilitated by the B-box region of CO.
DYRK4 upregulates antiviral innate immunity by promoting IRF3 ...
2024年12月19日 · DYRK4 is a member of the conserved dual-specific tyrosine phosphorylation-regulated kinase (DYRK) family, which contains five members (DYRK1A, DYRK1B, DYRK2, DYRK3, and DYRK4) and has a conserved N-terminal DYRK homology cassette (DH) and an adjacent kinase domain (Aranda et al, 2011).It has a highly conserved Tyr-X-Tyr amino acid motif in the catalytic domain of the activation loop, and ...
Fermentation for future food systems: - EMBO reports
2021年4月27日 · The growing human population and global warming pose an impending threat for global food security (Linder, 2019).This has prompted a critical re‐examination of the food supply chain from producers to consumers in order to increase the overall efficiency of food production, storage and transport.