CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily [5] and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). [6]

Here, we review the role of CD47 in the maintenance of immune system homeostasis. We also depict three emerging CD47-targeting strategies for cancer therapy, including the use of mimicry peptides, antibodies, and gene silencing strategies.

2024年12月24日 · CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Hemolytic Anemia . Among its related pathways are Innate Immune System and Integrin Pathway .

CD47 (originally named integrin-associated protein (IAP)) is a cell surface protein of the immunoglobulin (Ig) superfamily, which is heavily glycosylated and expressed by virtually all cells in the body .

CD47 is a widely expressed integral membrane protein that serves as the counter-receptor for the inhibitory phagocyte receptor signal-regulatory protein-α (SIRPα) and as a signaling receptor for the secreted matricellular protein thrombospondin-1. ...

Many therapeutic products targeting CD47 are being developed, including anti-CD47 mAbs, bi-specific antibodies (BsAbs) to CD47 and other molecules, as well as SIRPα-related fusion proteins. Some of the therapeutic products have demonstrated promising …

CD47 is a kind of protein that is found on the surface of many cells in the body. It tells circulating immune cells called macrophages not to eat these cells. The body uses the CD47 protein to protect cells that should be protected and to help dispose of cells that are aged or diseased.

CD47 blockade can cause anemia and other hematological toxicities [[80], [81], [82]] due to the phagocytosis of healthy red blood cells, which express CD47 [83] as a “don't eat me” signal to prevent their destruction by macrophages in the spleen and liver. The degree of toxicity can depend on the dose, timing, and baseline health status of ...

2025年1月25日 · Moreover, CD47 expression was positively correlated with the activation of immunological signaling pathways and enrichment of immune cell subpopulations in OvCa. Furthermore, in breast cancer and gynecological cancers, CD47, specially expressed in tumor cells, also showed favorable ability to distinguish the immune-hot and cold carcinomas.

The transmembrane protein, CD47, is recognized as an important innate immune checkpoint, and CD47-targeted drugs have been in development with the aim of inhibiting the interaction between CD47 and the regulatory glycoprotein SIRPα, for antitumor immunotherapy.