Many bacteriophages can modulate host transcription. Here, the authors uncover the anti-termination mechanism of phage satellite P4 protein, Psu. Psu dimers clamp two open rings of the termination ...
Opens in a new tab or window The antiviral drug valaciclovir (Valtrex), given prophylactically, kept patients with systemic lupus erythematosus (SLE) under treatment with anifrolumab (Saphnelo ...
For the multifaceted and complex diseases, multi-omics could define groups of patients with distinct endotypes exhibiting heterogeneous treatment responses due to their particular underlying molecular ...
Activating agents enable the efficient preparation of organozinc complexes from zinc metal and organohalides, but their mechanisms had been obscured by the heterogeneous nature of these systems.
From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...
New research identifies key cellular mechanism driving Alzheimer's disease. ScienceDaily . Retrieved January 20, 2025 from www.sciencedaily.com / releases / 2024 / 12 / 241223135051.htm ...
Anifrolumab is under clinical development by AstraZeneca and currently in Phase III for Polymyositis. According to GlobalData, Phase III drugs for Polymyositis does not have sufficient historical data ...
Anifrolumab is under clinical development by AstraZeneca and currently in Phase II for Vitiligo. According to GlobalData, Phase II drugs for Vitiligo have a 42% phase transition success rate (PTSR) ...
School of Materials Science and Engineering, Key Laboratory of Automobile Materials of MOE, Electron Microscopy Center, Jilin University, Changchun 130012, China ...
In a new study, the drug, deucravacitinib, proved to be a safe and more effective treatment for cutaneous lupus erythematosus disease (CLE, lupus skin disease) than two other commonly used therapies, ...
Employing gene-technological methods such as CRISPR-Cas9 genome editing, they were able to establish the molecular mechanisms of how mitochondria counteract cellular NAD decline. "Decreased ...
Unraveling these mechanisms would offer therapeutic options to ameliorate or perhaps even cure disorders that are now leading causes of mortality. In this millenium, we will be required to answer ...